You will have to assess it on a case-by-case situation. Another tough decision. If you feel the other person is drawing or has a weaker kicker on his four, then you will want to bet and hope he folds. If it took him a medium amount of time to call your flop, he's probably got a four of a kind, because he's trying to make a decision on if you have a queen or not.
If it took him a long time, you can expect him to have pocket pair (again, has to think about if you have queens or not) or he has Queens and he wants to suck you in. If you do end up betting the turn and don't get re-raised, you pretty much have to check down the river as you can no longer get him out by then obviously.
While on the subject of trips, I have to say that it's better to bluff on smaller trip threats. For example: 2/2/J vs J/J/2. Someone is far more likely to be holding a Jack as opposed to a 2, simply because average-strong players will rarely hold a 2 except for A2s, K2s, Q2s. In the SB or BB, this is a good bluff as others will be more apt to believe you are holding a 2. If you bluffed on the button, most people will put you on the Jack for the very same reasoning above.
So in short, bluffs high trips in late position. Bluff the turn if needed, but almost never the river because by then they'll usually call.
Now that bluffing has somewhat been covered, realize that other players will also try to make moves (be aggressive) in these levels. You'll tend to see mid-pairs betting out, or flush draws bet out even. This makes it a perfect time to trap people yourself if you hold a strong hand. Top pairs will usually be reluctant to slow play in these levels, as they don't want anyone drawing on them. So if the board doesn't have any kind of possible straight/flush threat that can develop, you may just check/call the flop then check-raise the turn. It'll help your image if you win, as others won't be able to bet all over you later in the game, which is important.
In late position, if the board is non-threatening, you may even check it down to give others a free card and hope someone pairs on the turn. Being check raised on the turn after checks on the flop is a really scary scenario for most players. Ideas of two pair and trips usually develop in this situation, as many people automatically don't even begin to think of someone checking over pair on the flop.
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